A Landscape Of Metabolic Variation Across Tumor Types?


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Frequently Asked Questions

Which is an example of a metabolic landscape?

In two representative human cancers, melanoma and head and neck, we apply this algorithm to define the intratumor metabolic landscape. We report an overall discordance between analyses of single cells and those of bulk tumors with higher metabolic activity in malignant cells than previously appreciated.

How is metabolism related to the tumor microenvironment?

Taken together this analysis establishes a computational framework for characterizing metabolism using single cell expression data and defines principles of the tumor microenvironment. Metabolic reprogramming in cancer cells supports specific demands for energy, biomass, redox maintenance, and cellular communication 1.

How is the metabolism of a tumor shaped?

Cellular metabolism is shaped by both genetic and environmental factors including the somatic driver mutations selected during tumor evolution, the tissue of origin, and the local nutrient environment 1, 2, 3, 4, 5.

How is metabolic landscape defined at single cell resolution?

However, a characterization of metabolic heterogeneity at single-cell resolution is not established. Here, we develop a computational pipeline to study metabolic programs in single cells. In two representative human cancers, melanoma and head and neck, we apply this algorithm to define the intratumor metabolic landscape.

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